Some of the designs (such as a lion, a dinosaur, and a bird) were featured as part of Noggin's channel logo, both in promotions for Play with Me Sesame and in general use. The background designs, many of which resemble a child's crayon drawings, are the same ones featured in Noggin's Moose and Zee interstitials. These include the title sequence, the Sesame Computer game segments, and the background designs. The show's backgrounds and animated elements were created at Nickelodeon Digital in New York. Tom Ascheim, one of the show's producers and the general manager of Noggin, said 'all the things kids do-running around, coloring, playing computer games-are funneled into the experience.' The format was meant to mimic a child's playdate. The show encourages its young viewers to join in on the movement and learning they see onscreen, making television an active experience rather than a passive one. Play with Me Sesame was the first long-form preschool series created by and for Noggin.

Reruns moved to PBS Kids Sprout, where it aired until May 14, 2016. It last aired on Noggin on September 2, 2007. At its launch, it was announced that Play with Me Sesame would continue to be produced for Noggin through 2009, but the show instead wrapped in 2007. Noggin also launched a live show, called Noggin's Play with Me Sesame Mall Tour, across the United States. Nickelodeon extensively promoted the show across all of their networks, using a musical infomercial sung by Grover. The show was heavily linked with Noggin's website,, and it featured a regular segment where computer games from Noggin were played. Play with Me Sesame premiered on Apand ran for three seasons.

Many of the background designs in Play with Me Sesame were simultaneously used in Nickelodeon's Moose and Zee interstitials. Kidscreen reported that 'the series marks the first time a State-side entity other than Sesame Workshop has been given permission by Henson to use the Sesame Street Muppets.' Noggin shot footage of the characters on a green screen, and animators at Nick Digital added in new graphics. To start production, Nickelodeon had to seek approval from Henson. The show began development in 1999, when the Jim Henson Company still co-owned the rights to the Sesame characters. To do this, they combined classic Sesame Street footage with new segments, where the hosts invite preschoolers to join them in games. Nickelodeon and Sesame developed the show to expand on Sesame Street by directly encouraging young viewers to interact with the characters. The series' backgrounds and animated elements were made by Nickelodeon Digital in New York City. It is a spin-off of Sesame Street hosted by Ernie, Bert, Prairie Dawn, and Grover. Play with Me Sesame is an American children's television series, created by Sesame Workshop and Nickelodeon for their former joint venture Noggin.

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